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Updated: Jul 14, 2026
09:48
Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
Non-hormonal cell types in the pituitary candidating for stem cell
1Laboratory of Cell Pharmacology, Department of Molecular Cell Biology, Campus Gasthuisberg O&N1, Herestraat 49, University of Leuven (K.U.Leuven), B-3000 Leuven, Belgium. Hugo.Vankelecom@med.kuleuven.be
Seminars in Cell & Developmental Biology
|May 19, 2007
Summary
The pituitary gland
Area of Science:
- Endocrinology and cell biology
- Neuroendocrinology
- Pituitary gland research
Background:
- The pituitary gland regulates hormone balance via diverse cell types.
- Cellular plasticity in the pituitary is crucial for adapting to endocrine demands.
- Understanding pituitary cell dynamics is essential for endocrine health.
Purpose of the Study:
- To review current data on pituitary cellular plasticity.
- To explore mechanisms of pituitary cell proportion changes.
- To identify potential stem cell candidates within the pituitary.
Main Methods:
- Literature review of studies on pituitary cell populations.
- Analysis of proposed mechanisms for pituitary cellular plasticity.
- Focus on non-hormonal cell types as potential stem cells.
Main Results:
- Pituitary cellular plasticity involves dynamic changes in cell proportions.
- Proliferation and transdifferentiation are proposed mechanisms.
- Non-hormonal cells are investigated as potential pituitary stem cells.
Conclusions:
- Mechanisms of pituitary cellular plasticity remain incompletely understood.
- The origin of new pituitary cells, particularly from stem cells, requires further investigation.
- Identifying pituitary stem cells is key to understanding gland regulation.
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