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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
T-cell and NK-cell posttransplantation lymphoproliferative disorders
1Department of Pathology, Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
American Journal of Clinical Pathology
|May 19, 2007
Summary
Posttransplantation lymphoproliferative disorders (PTLDs) involving T-cell or natural killer (NK)-cell origin are rare. Epstein-Barr virus-positive (EBV+) PTLDs show significantly longer survival than EBV-negative (EBV-) cases.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Posttransplantation lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations.
- PTLDs of T-cell or natural killer (NK)-cell origin are uncommon and fulfill criteria for T- or NK-cell lymphomas/leukemias.
Framework:
- This report summarizes 130 T/NK-cell PTLDs from literature and a workshop.
- Analysis focuses on clinical presentation, subtypes, and outcomes.
Implementation:
- T/NK-cell PTLDs typically occur 66 months post-transplant and are often extranodal.
- Common types include peripheral T-cell lymphoma, unspecified, and hepatosplenic T-cell lymphoma.
- Approximately one-third of cases are Epstein-Barr virus-positive (EBV+).
Implications:
- Median survival for T/NK-cell PTLDs is 6 months.
- EBV+ cases demonstrate significantly longer survival compared to EBV- cases.
- Treatment strategies vary, with some patients responding well to chemotherapy and reduced immunosuppression, while others improve without intensive therapy.
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