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Updated: Jul 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

The long-term outcome of 93 patients with proliferative lupus nephritis

Gabriella Moroni1, Silvana Quaglini, Beniamina Gallelli

  • 1Unita' Operativa di Nefrologia e Dialisi, Fondazione Ospedale Maggiore Policlinco, Mangiagalli, Regina Elena IRCCS, Via F. Sforza, Milano, and Dipartimento di Informatica e Sistemistica, Universita' degli Studi di Pavia, Italy. gmoroni@policlinico.mi.it

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|May 19, 2007
PubMed

Insights

Long-term outcomes for proliferative lupus nephritis show good renal survival. Achieving complete remission and avoiding flares are key to favorable prognosis in these patients.

Area of Science:

  • Nephrology
  • Immunology
  • Internal Medicine

Background:

  • Limited data exist on the very long-term prognosis of patients diagnosed with proliferative lupus nephritis.
  • Proliferative lupus nephritis is a severe manifestation of systemic lupus erythematosus affecting the kidneys.

Purpose of the Study:

  • To evaluate the very long-term renal outcome and survival rates in a cohort of Italian patients with biopsy-proven proliferative lupus nephritis.
  • To identify factors associated with favorable or unfavorable long-term outcomes in this patient group.

Main Methods:

  • An observational study included 93 Italian patients with biopsy-proven proliferative lupus nephritis.
  • Patients were followed for a median of 15 years, receiving induction therapy with corticosteroids and immunosuppressants, followed by maintenance therapy.
  • Treatment was repeated for renal flares, with subsequent dose reduction for maintenance.

Main Results:

  • Renal survival was 97% at 10 years and 82% at 20 years. At last follow-up, 59 patients achieved complete remission, 18 partial remission, six reached end-stage renal disease, and six died.
  • Lack of complete remission and nephritic flares significantly correlated with increased risk of doubling plasma creatinine and death or dialysis.
  • Patients achieving complete remission had a lower probability of developing nephritic flares.

Conclusions:

  • The long-term prognosis for Caucasian patients with proliferative lupus nephritis may be more favorable than previously assumed.
  • Achieving complete renal remission is a significant factor for a good long-term outcome.
  • Absence of nephritic flares and their complete reversibility after treatment are favorable prognostic indicators.
Abstract

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