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Related Experiment Videos

Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man.

H S Lee1, H Y Meltzer

  • 1Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, Ohio.

Journal of Neural Transmission. General Section
|January 1, 1991
PubMed
Summary

Buspirone, a serotonin (5-HT)1A partial agonist, did not cause hypothermia in healthy volunteers. This suggests buspirone is a weaker agonist for 5-HT1A receptors mediating hypothermia than other similar drugs.

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Area of Science:

  • Pharmacology
  • Neuroscience

Background:

  • Serotonin (5-HT)1A receptors play a role in regulating body temperature.
  • Several 5-HT1A partial agonists, like ipsapirone and gepirone, have been shown to induce hypothermia.
  • The specific activity of buspirone at these receptors concerning thermoregulation is not fully understood.

Purpose of the Study:

  • To investigate whether buspirone, a 5-HT1A partial agonist, induces hypothermia in normal human volunteers.
  • To compare the hypothermic potential of buspirone with other known 5-HT1A agonists.

Main Methods:

  • A placebo-controlled, single-blind study was conducted.
  • Seventeen healthy volunteers participated in the study.
  • Body temperature changes were monitored after administration of buspirone or placebo.

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Main Results:

  • Buspirone administration did not result in a significant decrease in body temperature.
  • No hypothermic effect was observed in the participants receiving buspirone.
  • The results contrast with findings for other 5-HT1A partial agonists like ipsapirone and gepirone.

Conclusions:

  • Buspirone does not appear to mediate hypothermia through the same 5-HT1A receptor pathway as ipsapirone or gepirone.
  • Buspirone may exhibit weaker partial agonism at the specific 5-HT1A receptors involved in thermoregulation.
  • Further research is needed to elucidate the precise role of buspirone in thermoregulation.