Hyperlactemia can predict the prognosis of liver resection

Area of Science:

• Hepatobiliary Surgery
• Critical Care Medicine
• Metabolic Monitoring

Background:

• Hyperlactatemia is associated with hepatic failure and metabolic acidosis.
• Limited research exists on lactate's predictive value for outcomes post-liver resection.

Purpose of the Study:

• To investigate the predictive ability of arterial plasma lactate concentration for patient outcomes following hepatectomy.
• To assess the relationship between lactate and base excess (BE) with postoperative complications and mortality.

Main Methods:

• Prospective investigation of 151 consecutive patients undergoing hepatectomy.
• Measurement of arterial lactate and base excess (BE) upon intensive care unit (ICU) admission.
• Correlation analysis with postoperative outcomes, including mortality, complications, and bilirubin levels.

Main Results:

• Lactate levels were significantly higher in non-survivors and patients with complications (P < 0.001).
• Base excess was significantly lower in non-survivors (P < 0.001) and complicated cases (P = 0.004).
• Lactate demonstrated strong predictive power for mortality (AUC 0.86) and morbidity (AUC 0.82), independently predicting outcomes.

Conclusions:

• Arterial plasma lactate concentration on ICU admission is an excellent predictor of patient outcome after liver resection.
• Lactate levels correlate with postoperative complications and mortality.
• Lactate and BE are valuable biomarkers for assessing severity and predicting outcomes in liver surgery patients.