Related Experiment Video

Updated: Jul 14, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Association between nitric oxide levels on myocardial injury in non-ST elevation acute coronary syndromes

Mustafa Yazici1, Sabri Demircan, Kenan Durna

  • 1Department of Cardiology, Ondokuz Mayis University Medical Faculty, Kurupelit/Samsun 55139, Turkey. drmeyaz@hotmail.com

Journal of Thrombosis and Thrombolysis
|May 19, 2007
PubMed

Insights

Lower nitric oxide (NO) levels are linked to increased myocardial injury in non-ST elevation acute coronary syndromes (NSTE-ACS). This suggests NO plays a role in the severity of platelet-rich thrombus formation and cardiac damage.

Area of Science:

  • Cardiology
  • Biomedical Science
  • Vascular Biology

Background:

  • Non-ST elevation acute coronary syndromes (NSTE-ACS) involve platelet-rich thrombus formation due to impaired nitric oxide (NO) release.
  • Thrombus formation and distal embolization in NSTE-ACS increase the risk of myocardial injury.

Purpose of the Study:

  • To investigate the relationship between nitric oxide (NO) levels and troponin-I (Tn-I) in patients diagnosed with NSTE-ACS.
  • To determine if NO levels can predict myocardial injury markers in NSTE-ACS.

Main Methods:

  • Measured venous levels of nitric oxide (NO) and troponin-I (Tn-I) in 234 NSTE-ACS patients.
  • Categorized patients into Tn-I negative (<0.20 ng/ml) and Tn-I positive (≥0.21 ng/ml) groups.
  • Assessed coronary thrombus presence, Thrombolysis in Myocardial Infarction (TIMI) flow, and lesion morphology via coronary angiography.

Main Results:

  • Tn-I positive patients exhibited higher frequencies of coronary thrombus, impaired TIMI flow, complex lesions, angina, and ST-T changes.
  • Lower NO levels were observed in Tn-I positive patients, those with angina, and ST-T changes.
  • A significant negative correlation (r = -0.87, P < 0.001) was found between Tn-I and NO levels; NO independently predicted Tn-I status (r = 0.527, P < 0.001).

Conclusions:

  • Nitric oxide (NO) levels are significantly associated with myocardial injury in NSTE-ACS patients.
  • Reduced NO levels serve as an indicator of myocardial damage in the context of NSTE-ACS.
  • NO levels may be a valuable biomarker for assessing the extent of myocardial injury in NSTE-ACS.
Abstract

More Related Videos

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...