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Related Experiment Videos

Thrombin generation in cardiac device recipients.

P C Johnson1, K O Garrett, H L Borovetz

  • 1Department of Surgery, University of Pittsburgh, Pennsylvania 15261.

ASAIO Transactions
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

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Thrombin generation was elevated after left ventricular assist system (LVAS) and total artificial heart (TAH) implantation but normalized with anticoagulation. Elevated thrombin generation did not correlate with transient ischemic attacks (TIAs).

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Hematology

Background:

  • Left ventricular assist systems (LVAS) and total artificial hearts (TAH) are crucial for end-stage heart failure treatment.
  • Understanding the hemostatic balance post-implantation is vital for patient outcomes.
  • Thrombin generation plays a key role in the coagulation cascade and thrombotic risk.

Purpose of the Study:

  • To investigate thrombin generation levels in patients following LVAS and TAH implantation.
  • To assess the impact of anticoagulation therapy on thrombin generation.
  • To determine if elevated thrombin generation correlates with thromboembolic events.

Main Methods:

  • Thrombin generation assays were performed on blood samples from patients post-LVAS and TAH implantation.

Related Experiment Videos

  • Measurements were taken during the first postoperative week and after the initiation of anticoagulation.
  • Thromboembolic events, specifically transient ischemic attacks (TIAs), were monitored.

    • Main Results:

    • Thrombin generation was significantly elevated (threefold above normal) in the first postoperative week after LVAS and TAH implantation.
    • Anticoagulation therapy led to a decline in thrombin generation to normal levels.
    • Elevated thrombin generation was not observed at the time of the recorded TIAs.

    Conclusions:

    • LVAS and TAH implantation transiently increase thrombin generation, suggesting a prothrombotic state.
    • Anticoagulation effectively manages this heightened thrombin generation.
    • The study did not find a direct correlation between elevated thrombin generation and TIAs in this patient cohort.