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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

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Scleral MIRAgel causing bony orbital erosion.

Edwin C Figueira¹, Ian C Francis, Geoffrey A Wilcsek

¹Ocular Plastics Unit, Department of Ophthalmology, Prince of Wales Hospital, The University of New South Wales, Sydney, Australia.

Orbit (Amsterdam, Netherlands)

|May 19, 2007

Summary

A hydrogel scleral explant (MIRAgel) caused orbital complications ten years after implantation. Swelling led to atrophy, resulting in strabismus, double vision, and orbital roof dehiscence.

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Area of Science:

Ophthalmology
Ophthalmic Surgery
Biomaterials

Background:

Hydrogel scleral explants are used in ophthalmic reconstructive surgery.
Long-term complications of biomaterials require ongoing investigation.

Observation:

A case report details a patient with a MIRAgel hydrogel scleral explant.
The explant was placed ten years prior to the current presentation.

Findings:

The hydrogel explant exhibited swelling, causing pressure-related atrophy.
This resulted in incomitant strabismus, diplopia, enophthalmos, and dehiscence of the orbital roof.

Implications:

Delayed complications from hydrogel scleral explants are possible.
This case highlights the need for long-term monitoring of patients with such implants.
Understanding biomaterial-induced orbital changes is crucial for surgical planning and patient management.