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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...

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Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Published on: January 17, 2017

Solventless pharmaceutical coating processes: a review.

Sagarika Bose1, Robin H Bogner

  • 1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA. boses2@wyeth.com

Pharmaceutical Development and Technology
|May 19, 2007
PubMed
Summary

Solventless pharmaceutical coating technologies offer environmental and cost benefits over traditional methods. This review explores six solventless coating techniques for improved drug delivery and product quality.

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Chemical Engineering

Background:

  • Film coatings enhance pharmaceutical dosage forms' aesthetics, stability, and drug release.
  • Traditional aqueous or organic solvent-based coatings present disadvantages like solvent exposure and disposal issues.
  • Solventless coating technologies offer a sustainable and efficient alternative.

Purpose of the Study:

  • To review and compare six solventless coating methods for pharmaceutical dosage forms.
  • To highlight the advantages of solventless coating over conventional solvent-based techniques.
  • To present alternatives for coating temperature-sensitive drugs.

Main Methods:

  • Review and comparison of compression coating, hot-melt coating, supercritical fluid spray coating, electrostatic coating, dry powder coating, and photocurable coating.
  • Analysis of the principles, advantages, and limitations of each solventless method.
  • Discussion of their applicability in pharmaceutical formulation.

Main Results:

  • Solventless methods eliminate solvent-related drawbacks, reducing costs and processing time.
  • These techniques offer environmental benefits by avoiding solvent disposal.
  • Methods like hot-melt and photocurable coating can be used for temperature-sensitive drugs.

Conclusions:

  • Solventless coating technologies provide significant advantages in pharmaceutical manufacturing.
  • They offer greener, more cost-effective, and efficient alternatives to solvent-based coatings.
  • These methods expand the possibilities for formulating diverse pharmaceutical products.