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Influence of process parameters on pellets elaborated in a Mi-pro high-shear granulator
E Chevalier1, M Viana, C Pouget
1GEFSoD EA 2631, Faculté de Pharmacie, Laboratoire de Pharmacie Galénique, Limoges Cedex, France.
Pharmaceutical Development and Technology
|May 19, 2007
Summary
This study developed a wet granulation method to create porous pellets for drug embedding. Process parameter optimization allows control over pellet size, shape, and porosity for drug delivery applications.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Developing effective drug delivery systems requires precise control over the physical properties of excipients.
- Porous pellets offer a versatile platform for embedding and controlled release of active pharmaceutical ingredients.
Purpose of the Study:
- To prepare porous pellets suitable for drug embedding using wet granulation.
- To investigate the influence of process parameters on the physical characteristics of the pellets.
- To establish optimal granulation conditions for producing pellets with desired size, shape, and porosity.
Main Methods:
- Wet granulation of alpha-lactose and polyvinylpyrrolidone powder mixture.
- Utilized a Mi-Pro high-shear granulator.
- Systematically varied process parameters, including water volume, distribution rate, and impeller speed.
Main Results:
- Optimized granulation conditions yielded satisfactory pellet size and shape.
- Increased impeller speed led to larger granule size, higher granulation yield, and fewer fines.
- Achieved control over granule size, shape, surface area, and porosity through parameter adjustment.
- Granules exhibited excellent flow properties across all tested conditions.
Conclusions:
- Wet granulation is an effective method for producing controllable porous pellets.
- Process parameter optimization is crucial for tailoring pellet properties for drug embedding.
- The prepared granules are suitable for incorporating drug substances via deposition or inclusion.
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