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Updated: Jul 14, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and antitumor evaluation of benzopsoralen analogues
Ana M A G Oliveira1, Ana M F Oliveira-Campos, Lígia M Rodrigues
1Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Abstract:
The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2-6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure-activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity.
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