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Performance evaluation of hydroxylated and acylated silicone rubber coatings
C C Tsai1, M L Dollar, A Constantinescu
1Bioengineering Program, University of Texas Southwestern Medical Center, Dallas 75235-9031.
ASAIO Transactions
|July 1, 1991
Abstract:
Hydroxylated and C16 acylated silicone rubber films were prepared with enhanced albumin binding. Lee-White clotting times were significantly increased for both treatments. Hydroxylation significantly reduced C5a production. Hydroxylated silicone rubber femoral vein catheters in canines reduced 111In-labeled platelet activity, compared with bilateral silicone rubber catheter controls. The results suggest hydroxylated silicone rubber films have enhanced biocompatibility.