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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

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Related Experiment Video

Updated: Jul 14, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Hydrogel-Based BioMEMS platforms for smart drug delivery.

Babak Ziaie, Ronald A Siegel

    Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
    |May 22, 2007
    PubMed
    Summary

    Environmentally sensitive hydrogels enable smart microfluidic flow control. These materials exhibit significant volume changes in response to stimuli like glucose, ideal for implantable drug delivery systems.

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    Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
    09:39

    Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

    Published on: February 7, 2021

    Area of Science:

    • Materials Science
    • Biomedical Engineering
    • Microfluidics

    Background:

    • Environmentally sensitive hydrogels possess tunable properties for microfluidic applications.
    • Their abrupt swelling phase transition, up to 1000-fold volume change, is key for microactuators.
    • Hydrogels are suitable for aqueous environments, including biological fluids, for applications like drug delivery.

    Purpose of the Study:

    • To discuss hydrogel-actuated Micro-Electro-Mechanical Systems (MEMS) for smart microflow control.
    • To highlight specific microdevices developed for advanced microfluidic applications.
    • To focus on poly(methacrylamidophenylboronic acid-co-acylamide) hydrogels for glucose-responsive applications.

    Main Methods:

    • Development of hydrogel-actuated MEMS microdevices.
    • Design of microvalves and flow controllers utilizing hydrogel swelling properties.
    • Investigation of poly(methacrylamidophenylboronic acid-co-acylamide) hydrogel response to glucose concentration at pH 7.4.

    Main Results:

    • Demonstration of several hydrogel-actuated microdevices, including microvalves and flow controllers.
    • Successful implementation of hydrogels as microactuators in aqueous media.
    • Observation of monotonic swelling in specific hydrogels with increasing glucose concentration at pH 7.4.

    Conclusions:

    • Hydrogel-actuated MEMS offer promising solutions for smart microflow control.
    • These systems are well-suited for applications requiring actuation in biological fluids, such as implantable drug delivery.
    • The studied hydrogels show potential for wireless, passive glucose monitoring and control systems.