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Related Experiment Videos

Enteropathy-type T-cell lymphoma.

Andreas Zettl1, Ron deLeeuw, Eugenia Haralambieva

  • 1The Institute of Pathology, University of Würzburg, Würzburg, Germany.

American Journal of Clinical Pathology
|May 22, 2007
PubMed
Summary
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Enteropathy-type T-cell lymphoma (ETL) is a rare gastrointestinal cancer. Two distinct histologic groups of ETL show correlation with clinical, immunophenotypic, and genomic features, aiding diagnosis.

Area of Science:

  • Hematopathology
  • Gastrointestinal Oncology
  • Oncologic Pathology

Background:

  • Enteropathy-type T-cell lymphoma (ETL) is a rare T-cell lymphoma affecting the gastrointestinal tract.
  • ETL is frequently associated with celiac disease and typically originates in the jejunum.
  • This lymphoma can also involve other gastrointestinal sites, including the stomach and colon.

Purpose of the Study:

  • To present case studies and discuss enteropathy-type T-cell lymphoma (ETL) and other T-cell lymphomas of the gastrointestinal tract.
  • To highlight the distinct histologic, clinical, and immunophenotypic features of ETL subtypes.
  • To explore the utility of comparative genomic hybridization in diagnosing ETL.

Main Methods:

  • Case presentations and expert discussion from the Society for Hematopathology/European Association for Haematopathology Workshop.

Related Experiment Videos

  • Histologic examination of tumor samples to identify pleomorphic-anaplastic and monomorphic subtypes of ETL.
  • Immunophenotypic analysis, including CD56 expression, to differentiate ETL subtypes.
  • Comparative genomic hybridization (CGH) to identify characteristic chromosomal abnormalities in ETL.

    • Main Results:

    • Two main histologic groups of ETL were identified: pleomorphic-anaplastic ETL and monomorphic ETL.
    • Pleomorphic-anaplastic ETL is typically CD56- and associated with celiac disease and enteropathy.
    • Monomorphic ETL is usually CD56+, may lack a celiac disease history, and shows variable enteropathy.
    • CGH revealed recurrent chromosomal gains and losses specific to ETL, distinguishing it from other T-cell lymphomas.

    Conclusions:

    • ETL can be classified into two distinct histologic groups with correlating clinical and immunophenotypic characteristics.
    • CD56 expression and history of celiac disease are key features differentiating ETL subtypes.
    • Genomic alterations identified by CGH provide valuable diagnostic support for ETL.