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Updated: Jul 14, 2026

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
Published on: November 5, 2016
[Preparation and evaluation of sustained-release microsphere of Sanguis Draconis in vitro]
Li-Yu Ding1, Peng-Fei Xia, Cai-Qin Yang
1Department of Inorganic and Physical Chemistry, College of Pharmacy Hebei Medical University, Shijiazhuang 050017, China. ding5622@163.com
Objective:
To prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro.
Method:
Sustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied.
Result:
The microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76. 71% in 16 hours.
Conclusion:
The sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications.

