Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Pharynx01:20

Pharynx

The pharynx, a tubular structure framed by skeletal muscle and lined with mucous membrane, extends continuously from the nasal cavities. It is segmented into three major areas: the nasopharynx, oropharynx, and laryngopharynx.
Nasopharynx
The nasopharynx, bordered by the conchae of the nasal cavity, serves exclusively as an air conduit. In its superior region, the pharyngeal tonsils or adenoids are located. These tonsils are clusters of lymphoid reticular tissue akin to a lymph node. The precise...
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Congenital Kir6.2 deficiency, but not acute K<sub>ATP</sub> channel blockade, attenuates apomorphine-induced locomotor activity in mice.

Pharmacology, biochemistry, and behavior·2026
Same author

SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized Mice.

Molecular neurobiology·2026
Same author

AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.

Neurochemistry international·2026
Same author

Effects of sacubitril/valsartan according to daily salt intake and comparison with thiazide add-on treatment in patients with uncontrolled hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension·2025
Same author

Comparison of renal effects between sacubitril/valsartan and thiazide diuretics among patients with uncontrolled hypertension and chronic kidney disease in Japan.

Clinical and experimental nephrology·2025
Same author

Neuronal dysfunction in the amygdala is involved in anxiety-like behaviors accompanying ulcerative colitis.

Neuroscience letters·2025

Related Experiment Video

Updated: Jul 14, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

[Laryngopharyngeal reflux].

Hiroshi Takeda1, Nobuhiko Oridate, Yuichi Shimizu

  • 1Department of Gastroenterolgy and Hematology, Hokkaido University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 22, 2007
PubMed
Summary

Laryngopharyngeal reflux (LPR) may not improve with proton pump inhibitors (PPIs). Current evidence suggests PPIs offer no significant benefit over placebo for LPR treatment, necessitating further research.

More Related Videos

Minimally Invasive Murine Laryngoscopy for Close&#45;Up Imaging of Laryngeal Motion During Breathing and Swallowing
07:45

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

Related Experiment Videos

Last Updated: Jul 14, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Minimally Invasive Murine Laryngoscopy for Close&#45;Up Imaging of Laryngeal Motion During Breathing and Swallowing
07:45

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

Area of Science:

  • Otolaryngology
  • Gastroenterology

Context:

  • Laryngopharyngeal reflux (LPR), or reflux laryngitis, involves stomach content backflow into the throat.
  • LPR is linked to symptoms like hoarseness, chronic cough, and throat pain.

Purpose:

  • To evaluate the efficacy of proton pump inhibitors (PPIs) in treating Laryngopharyngeal reflux (LPR).

Summary:

  • Diagnosis of LPR often relies on symptoms and laryngeal signs.
  • Empiric double-dose PPI therapy is a common first-line treatment for suspected LPR.
  • A recent review indicated no significant benefit of PPIs over placebo for LPR treatment.

Impact:

  • Highlights the need for more rigorous, large-scale clinical trials to establish effective LPR treatments.
  • Challenges the current standard of care for LPR management.
  • Informs clinical practice regarding PPI use in LPR patients.