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Microbially infected thrombus in animals with total artificial hearts
B Y Chiang1, G L Burns, G M Pantalos
1Institute for Biomedical Engineering, University of Utah, Salt Lake City 84103.
ASAIO Transactions
|July 1, 1991
Summary
Microbially infected thrombi (MIT) affected 31% of animals with total artificial hearts (TAH), rising to 75% in long-term survivors. Pseudomonas was the most common pathogen, often linked to device components.
Area of Science:
- Biomedical Engineering
- Infectious Diseases
- Veterinary Medicine
Background:
- Total artificial hearts (TAH) are critical for end-stage heart failure.
- Thrombus formation and subsequent infection pose significant risks in TAH recipients.
- Understanding microbially infected thrombi (MIT) is crucial for improving TAH outcomes.
Purpose of the Study:
- To investigate the incidence and characteristics of microbially infected thrombi (MIT) in animals with TAH.
- To identify common pathogens and potential origins of MIT.
- To inform strategies for preventing MIT in TAH patients.
Main Methods:
- Retrospective analysis of 330 animals implanted with TAH.
- Examination of explanted devices and associated thrombi for microbial infection.
- Identification of isolated pathogens and analysis of thrombus location.
Main Results:
- 103 out of 330 (31%) animals developed MIT.
- MIT incidence reached approximately 75% in animals surviving over 100 days.
- Pseudomonas was the most frequent pathogen; thrombi often originated from valve junctions and connectors.
Conclusions:
- MIT is a common complication in TAH recipients, particularly with longer survival.
- Preventive strategies should focus on reducing thrombus formation and controlling bacterial entry.
- Further research is needed on host-device-microbe interactions post-TAH implantation.