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Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Periodontitis: an archetypical biofilm disease.

Journal of the American Dental Association (1939)·2009
Same author

Oral biofilm: entry and immune system response.

Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)·2009
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Managing periodontal disease in a patient suffering from renal failure.

Dentistry today·2008
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Management of periodontitis for HIV-AIDS patients: case study.

Dentistry today·2006

Related Experiment Video

Updated: Jul 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Oral periopathogens and systemic effects.

John Costerton1, Duane Keller

  • 1Center for Biofilms, School of Dentistry, University of Southern California, Los Angeles, USA.

General Dentistry
|May 22, 2007
PubMed
Summary

Managing oral biofilms is crucial for preventing periodontal disease and decay. Controlling oral pathogens offers significant systemic health benefits, impacting conditions like cardiovascular disease and diabetes.

Area of Science:

  • Oral health
  • Microbiology
  • Systemic health

Background:

  • Oral biofilms harbor pathogens linked to periodontal disease and decay.
  • The oral cavity acts as a portal for pathogenic microorganisms, potentially leading to systemic issues.
  • Systemic sequelae can arise when oral pathogens overwhelm an individual's resistance.

Purpose of the Study:

  • To highlight the systemic benefits of managing oral pathogens.
  • To underscore the link between oral pathology and various systemic diseases.
  • To inform about evolving insurance coverage for periodontal treatments.

Main Methods:

  • Review of current scientific evidence on oral biofilms and systemic health.
  • Analysis of the relationship between oral pathogens and systemic conditions.

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Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

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Last Updated: Jul 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
06:36

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Published on: March 14, 2025

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

  • Examination of trends in dental insurance coverage for periodontal care.

    • Main Results:

    • Controlling oral pathogens demonstrates significant systemic health benefits.
    • Oral pathology is associated with cardiovascular disease, respiratory disease, diabetes, and systemic inflammation.
    • Low birth weight and pre-term deliveries are linked to oral health status.
    • Insurance coverage for periodontal scaling is expanding for at-risk populations.

    Conclusions:

    • Effective management of oral biofilms is essential for both oral and systemic health.
    • Addressing oral pathogens can mitigate risks for serious systemic diseases.
    • Increased recognition of oral health's systemic impact is leading to improved patient access to care.