Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An integrated artificial heart-lung device.

E Tatsumi1, H Takano, Y Taenaka

  • 1National Cardiovascular Center Research Institute, Department of Artificial Organs, Osaka, Japan.

ASAIO Transactions
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia.

Rhinology·2024
Same author

Comment on "Ectopic thymic carcinoma of the parotid gland".

International journal of oral and maxillofacial surgery·2024
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth.

Science (New York, N.Y.)·2022
Same author

Amiodarone-induced pneumonitis.

QJM : monthly journal of the Association of Physicians·2021
Same author

Variations in color and reflectance on the surface of asteroid (101955) Bennu.

Science (New York, N.Y.)·2020
Same journal

Extracorporeal membrane oxygenation as a means of stabilizing and transporting high risk neonates.

ASAIO transactions·1991
Same journal

Pumping capabilities of the latissimus dorsi and rectus abdominis muscles wrapped around a valved pouch in a mock circulatory system.

ASAIO transactions·1991
Same journal

Causes of intraaortic balloon leaks.

ASAIO transactions·1991
Same journal

Influence of centrifugal blood pumps on the elasticity of erythrocytes.

ASAIO transactions·1991
Same journal

Reuse of "highly permeable" dialyzers with peroxyacetic acid as sole cleansing and disinfecting agent.

ASAIO transactions·1991
Same journal

Comparison of 50% dextrose water, 25% mannitol, and 23.5% saline for the treatment of hemodialysis-associated muscle cramps.

ASAIO transactions·1991
See all related articles

A new integrated artificial heart-lung device (IAHLD) offers simultaneous long-term support for both organs. Its innovative design ensures efficient gas exchange and uniform blood flow, paving the way for future clinical applications.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Technology
  • Respiratory Support Systems

Background:

  • Current artificial heart-lung devices face limitations in long-term efficacy and integration.
  • Simultaneous support for both heart and lung functions remains a significant challenge in critical care.

Purpose of the Study:

  • To develop and evaluate a novel integrated artificial heart-lung device (IAHLD) for simultaneous, long-term cardiac and pulmonary support.
  • To assess the structural, functional, and hemocompatibility characteristics of the IAHLD prototype.

Main Methods:

  • Design and fabrication of an integrated device comprising an artificial lung (LC) with composite hollow fiber membranes and pneumatic pusher-plate blood pumps.
  • Integration of LC between inlet and outlet pumps within a polyurethane housing.

Related Experiment Videos

  • Performance evaluation using gas exchange rate measurements (O2, CO2) and pump output assessment.
  • Flow visualization analysis using cineroentgenography to assess internal flow dynamics.

    • Main Results:

    • The prototype IAHLD demonstrated high gas exchange efficiency (up to 170 ml/min O2/CO2) and pump output (up to 5.5 L/min).
    • The device's structure prevented serum leakage, flow channeling, and stagnation, reducing blood-contacting surfaces.
    • Flow visualization confirmed uniform blood distribution within the IAHLD without stasis.

    Conclusions:

    • The integrated artificial heart-lung device (IAHLD) is a promising system for achieving simultaneous long-term heart and lung support.
    • The IAHLD's design offers high efficiency and uniform flow, suggesting potential for use without systemic heparinization after further thromboresistant surface development.