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Updated: Jul 14, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
Published on: February 6, 2018
Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?
1The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, VA 23518, USA. zalensao@evms.edu
Abstract:
Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put forward a hypothesis that the unique genome architecture in sperm provides a mechanism for orchestrated unpacking and ordered activation of the male genome during fertilization, thus offering an additional level of epigenetic information that will be deciphered in the descendant cells.
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