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Vasoactive intestinal peptide receptor expression in chronic periapical lesions
J Caviedes-Bucheli1, M M Azuero-Holguín, G C Moreno
1Department of Graduate Studies, School of Dentistry, Pontificia Universidad Javeriana, Bogota, Colombia. javiercaviedes@cable.net.co
International Endodontic Journal
|May 22, 2007
Summary
Vasoactive intestinal peptide (VIP) receptors are present in chronic periapical lesions. Their expression is higher in smaller lesions, indicating an inverse relationship between VIP receptor levels and lesion size.
Area of Science:
- Endocrinology
- Oral Pathology
- Molecular Biology
Background:
- Chronic periapical lesions are inflammatory responses to pulpal infection.
- Vasoactive intestinal peptide (VIP) is a neuropeptide with known roles in inflammation and tissue repair.
Purpose of the Study:
- To investigate the presence of VIP receptors in chronic periapical lesions using radioreceptor analysis.
- To determine if VIP receptor expression varies with the size of periapical lesions.
Main Methods:
- Radioreceptor analysis using (125)I-VIP was performed on twelve chronic periapical lesions.
- Lesions were categorized into two groups based on size (<5 mm and >5 mm).
- VIP receptor expression was quantified and compared between groups using Mann-Whitney's test.
Main Results:
- VIP receptors were detected in all examined periapical lesion samples.
- A statistically significant higher expression of VIP receptors was observed in lesions smaller than 5 mm (P < 0.001).
Conclusions:
- Chronic periapical lesions express VIP receptors.
- The level of VIP receptor expression is inversely proportional to the size of the periapical lesion.
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