Related Experiment Video
Updated: Jul 14, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Adult-onset Still's disease
1Department of Internal Medicine, Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. atayon@yahoo.com
International Journal of Clinical Practice
|May 22, 2007
Summary
Adult-onset Still's disease (AOSD) is a rare inflammatory condition. Turkish patients commonly present with fever, sore throat, rash, and joint pain, often accompanied by high ferritin and white blood cell counts.
Area of Science:
- Rheumatology
- Internal Medicine
- Clinical Immunology
Background:
- Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown cause.
- Characterized by fever, rash, arthralgia, and leukocytosis.
Purpose of the Study:
- To analyze the clinical and laboratory characteristics of AOSD in Turkish patients.
- To describe the presentation of AOSD in a tertiary referral center.
Main Methods:
- Retrospective analysis of 84 patients diagnosed with AOSD between 1990 and 2003.
- Inclusion based on established diagnostic criteria for AOSD.
Main Results:
- The majority of patients (70.2%) were female.
- Common symptoms included arthralgia (96.4%), fever (95.2%), arthritis (69%), and sore throat (65.5%).
- Elevated C-reactive protein, erythrocyte sedimentation rate (ESR), leukocytosis, and hyperferritinemia (>1000 ng/dl) were frequently observed.
Conclusions:
- Key initial findings in Turkish AOSD patients include high fever, sore throat, rash, polyarthritis, hyperferritinemia, and leukocytosis.
- Anemia and hypoalbuminemia were also noted.
- These characteristics aid in the diagnosis of AOSD in this population.
Related Concept Videos
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:26Diseases of the Liver and Gallbladder
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...