Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evaluation of a stented polyurethane mitral valve prosthesis.

D Hoffman1, D Sisto, L S Yu

  • 1Department of Cardiology and Cardiothoracic Surgery, Albert Einstein College of Medicine, Bronx, New York 10461.

ASAIO Transactions
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.

Nature immunology·2026
Same author

[The clinical characteristics and vestibular aqueduct morphology of Meniere's disease with or without migraine].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2026
Same author

[Psychological changes in tinnitus patients at different disease stages and related factors of comorbid somatic symptoms].

Zhonghua yi xue za zhi·2026
Same author

[Analysis of current research on recurrent sudden sensorineural hearing loss].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

Results from a phase Ib study of telisotuzumab vedotin in combination with osimertinib in patients with c-Met protein-overexpressing, EGFR-mutated locally advanced/metastatic non-small-cell lung cancer (NSCLC) after progression on prior osimertinib.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

[Preliminary analysis of risk factors of tinnitus related to female menopause].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2024

This study evaluated a polyurethane heart valve prosthesis. Despite calcification, the valve showed good medium-term function and no cerebral emboli, suggesting potential for temporary cardiac assist devices.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Medical Device Engineering

Background:

  • Polyurethane heart valve prostheses offer excellent physical properties but face challenges with thrombosis and embolism.
  • Existing research highlights the need for improved valve designs to mitigate these complications.

Purpose of the Study:

  • To assess the performance and durability of a vacuum-formed polyurethane tricuspid semilunar valve in the mitral position.
  • To evaluate the incidence of thromboembolism and calcification in this specific valve design.

Main Methods:

  • Implantation of 23 mm polyurethane tricuspid semilunar valves in the mitral position in eight sheep.
  • Utilized standard cardiopulmonary bypass and intermittent aortic cross-clamping techniques.
  • Post-implantation monitoring included echocardiography, anticoagulation with warfarin, and histological examination.

Related Experiment Videos

Main Results:

  • Two early valve failures occurred due to tears, leading to manufacturing process modifications.
  • Six sheep received modified valves, surviving 1-2.5 years post-implantation.
  • Echocardiography revealed valve calcification and increasing transvalvular gradients starting at 3 months.
  • Histological analysis showed no cerebral thromboembolism, though small renal calcium emboli were found without infarction.

Conclusions:

  • The modified polyurethane tricuspid semilunar valve demonstrated good medium-term function despite significant leaflet calcification.
  • Absence of cerebral emboli suggests a potentially reduced risk of stroke compared to earlier designs.
  • The valve's performance indicates possible utility in temporary cardiac assist devices.