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Related Experiment Videos

Peripheral circulation during nonpulsatile systemic perfusion in chronic awake animals.

Y Taenaka1, E Tatsumi, M Sakaki

  • 1National Cardiovascular Center, Department of Artificial Organs, Osaka, Japan.

ASAIO Transactions
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

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Peripheral circulation is adequately maintained during chronic nonpulsatile (NP) perfusion. This study in goats shows that NP flow supports tissue blood flow and body temperature distribution, crucial for survival.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Understanding peripheral circulation (PC) during nonpulsatile (NP) perfusion is limited.
  • Animals can survive chronic NP flow, but the underlying mechanisms require further investigation.

Purpose of the Study:

  • To analyze peripheral circulation in awake goats under chronic nonpulsatile systemic perfusion.
  • To assess hemodynamic, hormonal, tissue blood flow, and temperature distribution parameters.

Main Methods:

  • Established nonpulsatile total left heart bypass in goats using a centrifugal pump.
  • Measured hemodynamic parameters, hormonal levels (adrenalin, noradrenalin), ear tissue blood flow (laser Doppler), and body surface temperature distribution (thermography).

Main Results:

Related Experiment Videos

  • Nonpulsatile perfusion did not affect systemic vascular resistance or adrenalin/noradrenalin levels.
  • Tissue blood flow was well-maintained during NP perfusion, comparable to pulsatile flow.
  • Vasomotion was observed, indicating adequate peripheral circulation, and thermography showed no changes in temperature distribution.

Conclusions:

  • Peripheral circulation is adequately maintained in animals on chronic nonpulsatile systemic perfusion.
  • Nonpulsatile perfusion supports essential physiological parameters for sustained circulation.