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Published on: February 3, 2012
Hepatitis C virus infection, type III cryoglobulinemia, and necrotizing vasculitis
Isaac Brownell1, William Fangman
1New York University Department of Dermatology, USA.
Abstract:
A 53-year-old man with chronic hepatitis-C virus infection presented with livedo reticularis, purpura, and leg ulcers. A skin biopsy specimen showed a necrotizing vasculitis. The skin biopsy specimen and serology confirmed the diagnosis of type-III cryoglobulinemia. Bone marrow and peripheral blood showed proliferation of atypical CD5-positive B cells that included a monoclonal population. There is growing evidence that chronic hepatitis-C infection can result in immune dysregulation and expansion of autoimmune B cells that produce cryoglobulins.
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