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C-reactive protein gene polymorphism 1009A>G is associated with serum CRP levels in Chinese men: a TCVGHAGE study

Wayne H-H Sheu1, Yii-Der I Chen, Chen-Yuan Yu

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. whhsheu@vghtc.gov.tw

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 22, 2007
PubMed

Insights

Genetic variants in the C-reactive protein (CRP) gene, specifically the 1009A>G polymorphism, are linked to lower CRP levels in Chinese men. This suggests a genetic influence on inflammation markers relevant to cardiovascular disease risk.

Area of Science:

  • Genetics
  • Biochemistry
  • Cardiovascular Disease Research

Background:

  • Elevated high-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular disease.
  • While low-grade inflammation is a suspected cause, studies indicate genetic factors influence serum CRP concentrations.
  • The genetic basis of CRP levels is relevant across diverse ethnic groups.

Purpose of the Study:

  • To investigate the association between specific CRP gene variants and fasting hs-CRP concentrations.
  • To determine if genetic polymorphisms in the CRP gene influence hs-CRP levels in a cohort of Chinese men.

Main Methods:

  • Fasting hs-CRP concentrations were measured in 369 Chinese men.
  • Six polymorphisms within the CRP gene were analyzed using PCR-RFLP and direct sequencing.
  • Polymorphisms included 969T>C, 1009A>G, 1440C>A>T, 2667G>C, 3872A>G, and 5992T>A.

Main Results:

  • The CRP 1009A>G polymorphism showed a significant association with fasting hs-CRP concentrations in participants within the 5th to 95th percentile (n=328).
  • Individuals with GG genotypes had lower hs-CRP levels (0.072+/-0.062 mg/dl) compared to AG or AA genotypes (0.176+/-0.166 and 0.166+/-0.185 mg/dl, respectively).
  • Haplotypes carrying the 1009G allele were associated with the lowest CRP concentrations (P=0.05).

Conclusions:

  • CRP gene genotypes, specifically the 1009A>G polymorphism, are associated with reduced fasting hs-CRP concentrations.
  • Associated haplotypes also correlate with lower hs-CRP levels in elderly Chinese men.
  • These findings highlight the role of genetic variation in CRP levels and potential cardiovascular risk stratification.
Abstract

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