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Related Experiment Video

Updated: Jul 14, 2026

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Delayed blastocyst transfer: is the window shutting?

Bradley J Van Voorhis¹, Anuja Dokras

¹Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. brad-van-voorhis@uiowa.edu

Fertility and Sterility

|May 22, 2007

Summary

Embryo-endometrial asynchrony on day 6 may reduce pregnancy success in fresh embryo transfer cycles. Optimizing uterine receptivity is crucial for improved in vitro fertilization outcomes.

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Last Updated: Jul 14, 2026

Human Blastocyst Biopsy and Vitrification

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Published on: July 26, 2019

Modified MicroSecure Vitrification: A Safe, Simple and Highly Effective Cryopreservation Procedure for Human Blastocysts

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Published on: March 2, 2017

Morphometric Protocol for the Objective Assessment of Blastocyst Behavior During Vitrification and Warming Steps

Morphometric Protocol for the Objective Assessment of Blastocyst Behavior During Vitrification and Warming Steps

Published on: February 28, 2019

Area of Science:

Reproductive medicine
Embryology
Reproductive endocrinology

Background:

Embryo development and endometrial receptivity are critical for successful implantation.
Day 6 blastocysts represent a specific developmental stage often used in assisted reproductive technologies.

Discussion:

Data indicate a potential negative correlation between asynchronous development of day 6 blastocysts and the uterine lining.
This asynchrony may be a contributing factor to lower pregnancy rates observed in fresh embryo transfer cycles.

Key Insights:

A mismatch in developmental timing between the embryo and the endometrium can negatively impact implantation potential.
The developmental stage of the blastocyst (Day 6) and its synchrony with the endometrium are important considerations for fresh transfer success.

Outlook:

Further research is warranted to elucidate the mechanisms underlying embryo-endometrial dyssynchrony.
Investigating methods to assess and potentially correct this asynchrony could lead to improved clinical protocols and higher pregnancy rates in assisted reproduction.