Autoimmunity, oncornaviruses, and lymphomagenesis

The interactions between aberrant immune responses and C-type oncornaviruses in mice are complex. These viruses may be activated during certain immune responses, e.g., histocompatibility reactions, in the face of chronic immunosuppression. Oncornaviruses, themselves, may induce autoaggressive cell-mediated responses in certain lymphoid subpopulations, and these autoimmune reactions may be important in subsequent lymphomagenesis. Parallel events may occur in other animal models, e.g., the NZB mouse, and in certain human disorders, e.g., Sjögren's syndrome, systemic lupus erythematosus, and myasthenia gravis.