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Related Experiment Videos

Interleukin-1 kinetics in hemodialysis.

D Donati1, D Degiannis, L Homer

  • 1Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway.

ASAIO Transactions
|July 1, 1991
PubMed
Summary

Interleukin-1 (IL-1) levels are higher in hemodialysis (HD) patients. While HD temporarily reduces plasma IL-1, intracellular levels increase, and both cuprophan and polysulfone membranes bind and clear IL-1.

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Area of Science:

  • Nephrology
  • Immunology
  • Biochemistry

Background:

  • Patients undergoing maintenance hemodialysis (HD) exhibit elevated Interleukin-1 (IL-1) levels.
  • Elevated IL-1 is observed compared to both conservatively treated uremic patients and healthy individuals.

Purpose of the Study:

  • To quantify Interleukin-1 (IL-1) in plasma and mononuclear cell (MC) lysates of hemodialysis patients.
  • To investigate the impact of cuprophan (CU) and polysulfone (PS) membranes on IL-1 levels during hemodialysis.

Main Methods:

  • Measurement of IL-1 in plasma and MC lysates from HD patients using CU or PS membranes.
  • Comparison of IL-1 levels in HD patients versus conservatively treated uremic patients and healthy subjects.
  • In vitro assessment of IL-1 release and membrane binding/clearance properties.

Main Results:

  • Basal plasma IL-1 levels were significantly higher in HD patients.
  • Plasma IL-1 decreased during a single HD session but intracellular IL-1 content increased.
  • Both CU and PS membranes demonstrated the ability to bind and clear IL-1 in vitro.

Conclusions:

  • Hemodialysis is associated with elevated Interleukin-1 (IL-1) levels, both systemically and intracellularly.
  • While hemodialysis membranes reduce plasma IL-1 acutely, they also contribute to increased intracellular IL-1 production.
  • Both cuprophan and polysulfone membranes can bind and clear IL-1, suggesting a role in modulating IL-1 levels during treatment.

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