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Cytotoxic activity of lignans from Hibiscus cannabinus
Laila Moujir1, Ana M L Seca, Artur M S Silva
1Department of Microbiology and Cellular Biology, and Instituto Canario de Investigación del Cáncer, University of La Laguna, 38206 La Laguna, Tenerife, Spain. lmoujir@ull.es
Abstract:
The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds (2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they were in advanced stage of cellular division. The compounds did not exhibit antimicrobial activity.