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Placental lactogen is a haemopoietic hormone
1Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
British Journal of Haematology
|November 1, 1991
Summary
Human placental lactogen effectively treats anemia and thrombocytopenia in hypophysectomized rats. This hormone also stimulates bone marrow cell DNA synthesis, indicating its role as a potent hematopoietic factor.
Area of Science:
- Endocrinology
- Hematology
Background:
- Hypophysectomized (Hypox) rats exhibit anemia and thrombocytopenia.
- Bone marrow DNA synthesis is impaired in Hypox rats.
Purpose of the Study:
- To investigate the hematopoietic effects of human placental lactogen.
- To determine if human placental lactogen can correct anemia and thrombocytopenia in Hypox rats.
Main Methods:
- Daily treatment of Hypox rats with human placental lactogen.
- In vitro assessment of human placental lactogen's effect on rat bone marrow cells.
Main Results:
- Human placental lactogen corrected anemia and thrombocytopenia in Hypox rats.
- Placental lactogen normalized spontaneous DNA synthesis in Hypox rat bone marrow.
- Human placental lactogen demonstrated a direct mitogenic effect on bone marrow cells in vitro.
Conclusions:
- Human placental lactogen is a potent hematopoietic hormone.
- Placental lactogen plays a significant role in regulating blood cell production.