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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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Cutting edge: TLR2 directly triggers Th1 effector functions

Takayuki Imanishi1, Hiromitsu Hara, Shinobu Suzuki

  • 1Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.

Journal of Immunology (Baltimore, Md. : 1950)
|May 22, 2007
PubMed
Summary

Toll-like receptor 2 (TLR2) directly activates Th1 effector cells, promoting IFN-gamma production and cell survival independently of T cell receptor stimulation. This TLR2 function does not extend to Th2 cells, highlighting a specific role in Th1-mediated immunity.

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