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Oxidative stress and S100B protein in cirrhotic children

Luciana Ribeiro1, Ana Cristina Andreazza, Mirian Salvador

  • 1Laboratório de Psiquiatria Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. lribeiro@med.miami.edu

Neurochemical Research
|May 22, 2007
PubMed

Insights

This study found higher oxidative stress markers, superoxide dismutase (SOD) and TBARS, and lower catalase (CAT) activity in children with cirrhosis. S100B protein levels did not differ, but correlated negatively with TBARS.

Area of Science:

  • Pediatric Hepatology
  • Biochemistry
  • Neuroscience

Background:

  • Cirrhosis is the end-stage of chronic liver disease, leading to metabolic dysfunction and complications.
  • Oxidative stress and altered protein synthesis are key features of advanced liver disease.

Purpose of the Study:

  • To investigate serum S100B protein levels and oxidative stress markers in pediatric cirrhosis.
  • To explore potential correlations between S100B, oxidative stress, and astrocyte function in cirrhotic children.

Main Methods:

  • A case-control study involving 14 pediatric patients with cirrhosis.
  • Assessed serum S100B protein, superoxide dismutase (SOD) activity, catalase (CAT) activity, and TBARS (thiobarbituric acid reactive substances) levels.

Main Results:

  • No significant difference in S100B protein levels between cirrhotic and control groups.
  • Elevated SOD activity and TBARS levels, with reduced CAT activity in cirrhotic patients.
  • A significant negative correlation (r = -0.815, p = 0.001) between S100B and TBARS in the case group.

Conclusions:

  • Serum S100B levels may not serve as a direct marker for brain damage in pediatric cirrhosis.
  • Findings suggest a potential link between astrocyte function and oxidative damage in children with cirrhosis.
Abstract

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