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Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
Randomized clinical trial of single- versus multiple-dose antimicrobial prophylaxis in gastric cancer surgery
Y Mohri1, H Tonouchi, M Kobayashi
1Department of Gastrointestinal Surgery and Paediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan. ya-mohri@clin.medic.mie-u.ac.jp
Background:
The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still open to question. This multicentre randomized clinical trial compared a single-dose with a multiple-dose regimen of antimicrobial prophylaxis for prevention of surgical-site infection.
Methods:
Between May 2001 and December 2004, 501 patients undergoing elective surgery for gastric cancer in ten centres were allocated randomly to single- or multiple-dose antimicrobial prophylaxis. The primary outcome measure was the incidence of surgical-site infection, analysed by intention to treat.
Results:
Some 243 patients who received a single dose and 243 who received multiple doses of antibiotics were included in the final analysis. The surgical-site infection rate was 9.5 per cent (23 of 243) and 8.6 per cent (21 of 243) respectively (difference 0.9 (95 per cent confidence interval - 4.3 to 5.9) per cent). Antimicrobial prophylaxis had no major adverse effects.
Conclusion:
The incidence of surgical-site infection in elective gastric cancer surgery was similar with both antibiotic prophylaxis regimens.
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