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Related Experiment Videos

Cleft anterior segment with maternal hypervitaminosis A.

K Evans1, M U Hickey-Dwyer

  • 1University of Liverpool, Children's Unit, Alder Hey Hospital, Ophthalmology Department, West Derby.

The British Journal of Ophthalmology
|November 1, 1991
PubMed
Summary

Maternal vitamin A excess during pregnancy may cause rare congenital eye abnormalities, including an hourglass cornea and iris with a duplicated lens in infants. This case highlights potential teratogenic effects of high vitamin A intake.

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Area of Science:

  • Ophthalmology
  • Teratology
  • Developmental Biology

Background:

  • Congenital ocular anomalies represent a spectrum of developmental abnormalities.
  • Maternal health and nutritional status during pregnancy are critical for fetal development.
  • Vitamin A is essential but can be teratogenic at excessive doses.

Observation:

  • A case of a unilateral 'hourglass' cornea and iris is presented.
  • The affected eye also exhibited a reduplicated lens.
  • The infant was female and presented with these unique ocular malformations.

Findings:

  • The infant's mother reported excessive intake of vitamin A supplements during gestation.
  • This suggests a potential link between maternal hypervitaminosis A and the observed congenital eye defects.

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  • The specific mechanisms underlying these malformations are explored.

    • Implications:

    • This case underscores the importance of controlled vitamin A supplementation during pregnancy.
    • It provides insight into the teratogenic potential of vitamin A on ocular development.
    • Further research is warranted to elucidate the precise molecular pathways involved.