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Related Experiment Video

Updated: Jul 14, 2026

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
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Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology

Published on: August 23, 2024

Aqueous ginger extract ameliorates paraben induced cytotoxicity.

Veena Asnani1, Ramtej Jayram Verma

  • 1Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380009, India. zooldeptgu@satyam.net.in

Acta Poloniae Pharmaceutica
|May 23, 2007
PubMed
Summary

Aqueous ginger extract can protect red blood cells (RBCs) from paraben-induced damage. Ginger extract significantly reduced the rate of hemolysis caused by paraben in a dose-dependent manner.

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Area of Science:

  • Biochemistry
  • Toxicology
  • Pharmacology

Background:

  • Parabens are common preservatives with potential cytotoxic effects.
  • Red blood cells (RBCs) are vulnerable to oxidative stress and chemical damage.
  • Ginger (Zingiber officinale) possesses known antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To investigate the protective effects of aqueous ginger extract against paraben-induced cytotoxicity on human red blood cells in vitro.
  • To determine the concentration-dependent efficacy of ginger extract in mitigating paraben's hemolytic effects.

Main Methods:

  • Human RBC suspensions were prepared from blood samples collected in EDTA vials.
  • RBCs were exposed to paraben (p-hydroxybenzoic acid) alone and in combination with varying concentrations of aqueous ginger extract.

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Last Updated: Jul 14, 2026

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology
07:05

Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology

Published on: August 23, 2024

  • Hemolysis rate was measured to assess cytotoxicity and the protective effect of ginger extract.

    • Main Results:

    • Paraben exposure significantly increased the rate of red blood cell hemolysis.
    • Concurrent administration of ginger extract with paraben demonstrated a significant, concentration-dependent reduction in paraben-induced hemolysis.
    • The protective effect of ginger extract was observed to be dose-dependent, with higher concentrations offering greater protection.

    Conclusions:

    • Aqueous ginger extract exhibits a significant protective effect against paraben-induced cytotoxicity on human red blood cells.
    • Ginger extract can ameliorate paraben's hemolytic activity, suggesting potential therapeutic applications.
    • These findings highlight the potential of natural compounds like ginger in counteracting chemical-induced cellular damage.