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Published on: August 19, 2013
[Structure analysis of benzoic medicines by near infrared and two dimensional correlation spectroscopy]
Hao Liu1, Bing-ren Xiang, Ling-bo Qu
1Department of Pharmacy, Guangdong Chemical Engineering Pharmaceutics College, Guangzhou 510520, China.
Abstract:
The structure analysis of benzoic medicines by Fourier transform near infrared spectroscopy and generalized two dimensional correlation spectroscopy was performed. Three kinds of medicines showed unconspicuous changes in one-dimensional near infrared spectra, while the two dimensional correlation spectra showed high resolution, and were more explicable. By the comparison and analysis of raw near infrared spectra and 2D-correlation spectra, the near infrared absorption peaks of benzoic acid medicines were assigned, and their structure characteristics were analyzed, the results affirmed the six-membered ring intramolecular hydrogen bond especially. The study is helpful to the in-depth understanding of benzoic medicines, and provides information for the future study and utilization of benzoic medicines.
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