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Updated: Jul 14, 2026

Adult and Pediatric Porcine Model of Acute Volume Overload
Published on: January 12, 2024
[Reappraisal of perioperative fluid therapy in children]
1Department of Anesthesia, Faculty of Medicine, Kagawa University Kagawa 761-0793.
Insights
Hospital-acquired hyponatremia in children is a concern. Reducing intravenous fluid volumes and adding glucose to maintenance fluids may mitigate risks during the perioperative period.
Area of Science:
- Pediatric Medicine
- Intravenous Fluid Therapy
- Hyponatremia Management
Background:
- Hospital-acquired hyponatremia is a recognized risk in children receiving intravenous hypotonic fluids.
- Perioperative pediatric patients face risks of antidiuretic hormone (ADH) secretion and insulin resistance.
Purpose of the Study:
- To review hospital-acquired hyponatremia in children treated with intravenous hypotonic maintenance fluids.
- To discuss the advantages and disadvantages of adding glucose to intravenous fluids for pediatric patients.
Main Methods:
- Literature review of hyponatremia in pediatric perioperative care.
- Analysis of fluid composition and glucose supplementation strategies.
Main Results:
- Reduced intravenous fluid volumes (by 50%) and approximately 2% glucose concentration are suggested for perioperative pediatric patients.
- Controversy remains regarding the optimal fluid choice (isotonic vs. hypotonic) for postoperative maintenance, with weak evidence supporting either.
Conclusions:
- Adjusted fluid volumes and glucose concentrations are recommended to manage perioperative risks.
- Further research is necessary to determine the best fluid composition for postoperative maintenance in children.
Abstract:
Two recently recognized issues are reviewed ; one is a hospital acquired hyponatremia in children treated with intravenous hypotonic maintenance fluids and the other is the pros and cons of glucose addition to these fluids. Children in the perioperative period are at risk for nonosmotic secretion of ADH and stress-induced insulin resistance, which necessitate reducing the volume of maintenance fluid to half the previously recommended volume, and the concentration of additive glucose to approximately 2%. While isotonic fluids are recommended intraoperatively, controversies still exist on the constitution of maintenance fluids in the postoperative period, where the choice of an isotonic solution should be more pertinent to that of a hypotonic solution, but evidence is weak ; further investigations are needed to make a decision.
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