Search research articles

Search research articles

Related Experiment Videos

Development of the functionally total artificial heart using an artery pump.

Guo Rong Li¹, Xiao Dong Zhu

¹Department of Cardiac Surgery, Fu Wai Heart Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|May 23, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The UPR signaling molecule ATF6 is a poor prognostic marker in gastric cancer.

Asian journal of surgery·2022

Same author

Methanol extract of semen Ziziphi Spinosae attenuates ethanol withdrawal anxiety by improving neuropeptide signaling in the central amygdala.

BMC complementary and alternative medicine·2019

Same author

Acupuncture reduces nicotine-induced norepinephrine release in the hypothalamus via the solitary NMDA receptor/NOS pathway.

Neuroscience letters·2019

Same author

Cetuximab or Nimotuzumab Versus Cisplatin Concurrent with Radiotherapy for Local-Regionally Advanced Nasopharyngeal Carcinoma: a Meta-analysis

Asian Pacific journal of cancer prevention : APJCP·2018

Same author

Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center.

Annals of hematology·2016

Same author

Role of Cdk4 in lymphocyte function and allergen response.

Cell cycle (Georgetown, Tex.)·2010

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

A novel functionally total artificial heart (FTAH) concept utilizes two artery pumps (APs) to assist or replace diseased heart function without native heart resection. This approach demonstrates feasibility for maintaining cardiac output and pressures.

Area of Science:

Biomedical Engineering
Cardiovascular Devices
Artificial Organs

Background:

Diseased heart pump function often necessitates device assistance or replacement.
Current artificial heart designs may require extensive native heart resection.
A minimally invasive approach preserving native heart structures is desirable.

Purpose of the Study:

To explore the feasibility of a functionally total artificial heart (FTAH) concept.
To design and evaluate an artery pump (AP) for cardiac function support.
To assess the potential of APs to replace native heart pumping without resection.

Main Methods:

Designed and fabricated an artery pump (AP) with specific dimensions (28 mm OD, 42 mm length, 74 g weight, 29 mL volume).
Implanted APs in series with native ventricles (ascending aorta/pulmonary trunk position).

Related Experiment Videos

Tested two APs in mock circulation, evaluating flow rate balancing and pressure regulation.

Main Results:

Each AP achieved 5 L/min against 100 mm Hg at <10,000 rpm.
Two series-connected APs demonstrated automatic flow rate balancing.
Simulated cardiac output and atrial pressures were maintainable by adjusting pump speeds.
APs exhibited native-like responses to pressure changes, minimizing need for complex regulation.

Conclusions:

The functionally total artificial heart (FTAH) concept is feasible using two artery pumps (APs).
This approach offers a potential alternative to artificial hearts requiring native heart resection.
Further studies are warranted to validate the clinical applicability of this FTAH design.