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Related Concept Videos

Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Dosage Interval and Administration Route: Determination Methods01:19

Dosage Interval and Administration Route: Determination Methods

A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to individual...
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...

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Related Experiment Video

Updated: Jul 14, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
06:50

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

Published on: December 2, 2017

A refill adherence algorithm for multiple short intervals to estimate refill compliance (ReComp).

Chris L Bryson1, David H Au, Bessie Young

  • 1Health Services Research and Development Northwest Center of Excellence, Seattle, Washington 98101, USA. cbryson@u.washington.edu

Medical Care
|May 23, 2007
PubMed
Summary

A new refill adherence algorithm, ReComp, accurately measures medication adherence over short periods. ReComp outperforms existing methods in repeated measures analyses, improving patient adherence assessment.

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Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
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Last Updated: Jul 14, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
06:50

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

Published on: December 2, 2017

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Area of Science:

  • Pharmacoeconomics and Health Outcomes Research
  • Clinical Pharmacy and Practice
  • Health Services Research

Background:

  • Existing refill adherence measures lack validation for short observation periods and repeated measures designs.
  • Accurate assessment of medication adherence is crucial for evaluating treatment effectiveness.

Purpose of the Study:

  • To develop and validate a novel refill-based adherence algorithm (ReComp) for short observation intervals.
  • To compare the performance of ReComp against established adherence measures (MEDOUT, MEDSUM).

Main Methods:

  • A composite algorithm (ReComp) was created using medication gaps and oversupply data.
  • Electronic health records from the Veterans Affairs system were utilized.
  • Performance was evaluated in repeated measures analyses using simvastatin, antihypertensives, and beta-blockers over 30- and 90-day intervals.

Main Results:

  • ReComp demonstrated significantly higher correlation (R2 values) in adherence-response analyses compared to MEDSUM and MEDOUT.
  • The new measure consistently produced more expected adherence-response curves across all analyses.
  • In 30-day intervals, ReComp achieved an R2 of 0.231 for LDL-simvastatin, substantially higher than reference measures.

Conclusions:

  • The ReComp algorithm is superior for assessing medication adherence in short observation intervals with repeated measures.
  • This novel measure enhances the accuracy of adherence evaluation in clinical practice and research.