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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

Edema-induced intestinal dysfunction is mediated by STAT3 activation.

Karen S Uray1, Glen A Laine, Hasan Xue

  • 1Division of Pediatric Surgery, Department of Surgery, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA. karen.l.davis@uth.tmc.edu

Shock (Augusta, Ga.)
|May 23, 2007
PubMed
Summary

Signal transducer and activator of transcription 3 (STAT3) activation contributes to intestinal dysfunction caused by edema. Inhibiting STAT3 improved intestinal contractile activity in rats with edema.

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Published on: January 5, 2017

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Physiology

Background:

  • Increased signal transducer and activator of transcription 3 (STAT3) activation is linked to intestinal dysfunction.
  • STAT3 plays a critical role in cellular signaling pathways relevant to intestinal health.

Purpose of the Study:

  • To investigate the role of STAT3 in the development of intestinal dysfunction induced by edema.
  • To determine if STAT3 activation mediates changes in intestinal contractile activity during edema.

Main Methods:

  • Intestinal edema was induced in Sprague-Dawley rats using mesenteric venous hypertension and fluid resuscitation.
  • STAT3 activation (DNA binding, nuclear translocation, phosphorylation) and intestinal contractile activity were measured.
  • STAT3 activation was inhibited using AG490 to assess its functional impact.

Main Results:

  • Edema and increased STAT3 activation were observed in rats subjected to combined mesenteric venous hypertension and fluid resuscitation.
  • STAT3 activation significantly increased in edematous intestines, correlating with impaired contractile function.
  • Inhibition of STAT3 attenuated the decrease in intestinal contractile activity and myosin light chain phosphorylation.

Conclusions:

  • STAT3 activation is a key mediator of intestinal dysfunction associated with edema.
  • Targeting STAT3 may offer a therapeutic strategy for managing edema-induced intestinal motility disorders.