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Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
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Applying Taguchi methods for solvent-assisted PMMA bonding technique for static and dynamic micro-TAS devices.

Yi-Chu Hsu1, Tang-Yuan Chen

  • 1Department of Mechanical Engineering, Southern Taiwan University of Technology, Yung Kang City, Tainan County, Taiwan. yichu@mail.stut.edu.tw

Biomedical Microdevices
|May 23, 2007
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Optimizing solvent-assisted Polymethyl methacrylate (PMMA) bonding for microfluidic devices yields high strength and low dimension loss. This method enables robust fabrication of micro-total-analysis systems (micro-TAS).

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Area of Science:

  • Materials Science and Engineering
  • Microfluidics and Lab-on-a-Chip Technology

Background:

  • Polymethyl methacrylate (PMMA) is a common material for microfluidic devices.
  • Effective bonding techniques are crucial for fabricating reliable microfluidic systems, including micro-total-analysis systems (micro-TAS).

Purpose of the Study:

  • To investigate and optimize critical process parameters for solvent-assisted PMMA bonding.
  • To fabricate two distinct micro-TAS devices utilizing the optimized bonding parameters.
  • To evaluate the bonding strength, dimension loss, and compare the developed technique with existing methods.

Main Methods:

  • Utilized Taguchi's experimental design scheme to systematically analyze process parameters (heating temperature, applied loading, duration, solution).
  • Fabricated PMMA microfluidic chips with microchannels and microchambers using CO2 laser ablation.
  • Integrated static paraffin microvalves and dynamic diffuser micropumps into the micro-TAS devices.

Main Results:

  • Identified optimal bonding parameters leading to high bonding strength (240 kgf/cm²) and minimal dimension loss (2-6%).
  • Successfully fabricated two functional micro-TAS devices demonstrating the efficacy of the optimized bonding process.
  • The developed bonding technology exhibits normal stress 2-15 times greater than conventional methods like hot embossing and anodic bonding.

Conclusions:

  • Solvent-assisted bonding offers a superior method for fabricating PMMA-based microfluidic devices, particularly micro-TAS.
  • The optimized process ensures high structural integrity and performance for microfluidic applications.
  • This technique presents a significant advancement over existing bonding technologies in terms of strength and reliability.