Related Experiment Videos
Cardiomyopathies in children with neuromuscular disorders
I Malcić1, N Barisić, Z Brzović
1Department of Pediatrics, University Hospital Rebro, Medical Faculty, Zagreb, Croatia.
Neurologia Croatica : Glasilo Udruzenja Neurologa Jugoslavije = Official Journal of Yugoslav Neurological Association
|January 1, 1991
Summary
This study found that dilated cardiomyopathy is common in patients with neurogenic muscle diseases and progressive muscular dystrophy. Hypertrophic cardiomyopathy is more frequently observed in children with mitochondrial disorders.
Area of Science:
- Cardiology
- Neurology
- Genetics
Background:
- Cardiomyopathy is a significant concern in patients with myogenic or neurogenic muscle disorders.
- Understanding the specific types of cardiomyopathy associated with different muscle diseases is crucial for patient management.
Purpose of the Study:
- To investigate the prevalence and types of cardiomyopathy in patients with myogenic or neurogenic muscle disorders.
- To correlate specific muscle disorders with distinct cardiomyopathy presentations.
Main Methods:
- Case series presentation of eight patients with myogenic or neurogenic muscle disorders and co-existing cardiomyopathy.
- Clinical assessment and diagnostic evaluation of cardiac involvement in relation to the underlying muscle disease.
Main Results:
- Six patients developed dilated cardiomyopathy associated with neurogenic atrophies or progressive muscular dystrophy.
- Friedreich's Ataxia and High-Spinal Muscular Atrophy type II showed septal hypertrophy with total dilatation.
- Scapuloperoneal spinal muscular atrophy presented with atriomyopathy.
- Two patients with mitochondrial disorders exhibited hypertrophic cardiomyopathy.
Conclusions:
- Dilated cardiomyopathy is the most frequent cardiac complication in neurogenic muscle diseases and progressive muscular dystrophy.
- Hypertrophic cardiomyopathy is typically observed in pediatric patients with mitochondrial disorders.
- Restrictive cardiomyopathy was not observed in this patient cohort.