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Related Experiment Videos

Alterations in intrinsic neuronal excitability during normal aging.

John F Disterhoft1, M Matthew Oh

  • 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA. jdisterhoft@northwestern.edu

Aging Cell
|May 23, 2007
PubMed
Summary
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Aging impairs learning in tasks dependent on the hippocampus. This is linked to changes in hippocampal neurons, specifically increased afterhyperpolarization (AHP) and spike-frequency adaptation, hindering learning in older subjects.

Area of Science:

  • Neuroscience
  • Aging Research
  • Cognitive Science

Background:

  • Normal aging is associated with difficulties in hippocampus-dependent learning tasks.
  • Many aging animals, like rabbits and rats, fail trace eyeblink conditioning.
  • Reduced intrinsic excitability in hippocampal pyramidal neurons is a key factor in age-related learning deficits.

Purpose of the Study:

  • To review alterations in the postburst afterhyperpolarization (AHP) and spike-frequency adaptation (accommodation) during learning and normal aging.
  • To investigate the role of AHP and accommodation in age-related learning impairments.

Main Methods:

  • Review of existing literature on hippocampal function in aging.
  • Analysis of electrophysiological properties of hippocampal pyramidal neurons in aging subjects.

Related Experiment Videos

  • Focus on changes in postburst afterhyperpolarization (AHP) and spike-frequency adaptation (accommodation).

    • Main Results:

    • Aging is associated with an enlarged postburst afterhyperpolarization (AHP) in hippocampal pyramidal neurons.
    • Increased spike-frequency adaptation (accommodation) is observed in these neurons in aging subjects.
    • These changes in neuronal excitability correlate with impaired learning.

    Conclusions:

    • Age-related increases in postburst AHP and accommodation in hippocampal pyramidal neurons are integral to learning impairment in aging.
    • Targeting these neuronal changes may offer therapeutic strategies for age-related cognitive decline.