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Differential distribution of the endoplasmic reticulum network in filamentous fungi

Jun-ichi Maruyama1, Katsuhiko Kitamoto

  • 1Department of Biotechnology, The University of Tokyo, Tokyo, Japan.

FEMS Microbiology Letters
|May 23, 2007
PubMed

Insights

Filamentous fungi utilize a complex endoplasmic reticulum (ER) network for growth. This review details the ER

Area of Science:

  • Cell Biology
  • Mycology
  • Molecular Biology

Background:

  • Filamentous fungi grow as hyphae, with compartments separated by septa and communicating via pores.
  • Apical compartments elongate significantly before septum formation, exhibiting polarized organelle distribution.
  • Subapical compartments in Aspergillus can resume growth and mitosis through branching.

Purpose of the Study:

  • To discuss the spatial regulation of the endoplasmic reticulum (ER) network in multicellular filamentous fungi.
  • To highlight the differentiated localization and dynamic changes of the ER during hyphal growth and septum formation.

Main Methods:

  • Review of recent reports utilizing green fluorescent protein (GFP) technology.
  • Analysis of studies demonstrating ER network localization in various hyphal regions.

Main Results:

  • The endoplasmic reticulum (ER) network shows a gradient distribution from the apical region of hyphae.
  • Specific ER localization is observed along septa and differs between adjacent compartments.
  • The ER undergoes dynamic morphological changes during septum formation.

Conclusions:

  • The spatial organization of the ER network is crucial for hyphal development in filamentous fungi.
  • Understanding ER regulation provides insights into fungal growth mechanisms and cell differentiation.

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