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Cyclin D1 down-regulation is essential for DBC2's tumor suppressor function

Takashi Yoshihara1, Denise Collado, Masaaki Hamaguchi

  • 1Department of Biological Sciences, Fordham University, 441 E Fordham Road, Larkin Hall, Bronx, NY 10458, USA.

Biochemical and Biophysical Research Communications
|May 23, 2007
PubMed
Summary

The tumor suppressor gene DBC2 inhibits breast cancer cell growth by reducing Cyclin D1 (CCND1) levels. Overexpressing CCND1 counteracts DBC2

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