Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural probe design for reduced tissue encapsulation in CNS.

John P Seymour1, Daryl R Kipke

  • 1Department of Biomedical Engineering, University of Michigan, 2212 Lurie Biomedical Engineering Building, 1101 Beal Avenue, Ann Arbor, MI 48109-2099, USA.

Biomaterials
|May 23, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microelectrode arrays enable directional stereo-EEG during kainate-mediated seizures.

bioRxiv : the preprint server for biology·2026
Same author

Optimizing electrode placement and information capacity for local field potentials in cortex.

NeuroImage·2026
Same author

Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.

Journal of neural engineering·2025
Same author

Optimizing electrode placement and information capacity for local field potentials in cortex.

bioRxiv : the preprint server for biology·2025
Same author

Decoding articulatory and phonetic components of naturalistic continuous speech from the distributed language network.

Journal of neural engineering·2023
Same author

Sensing local field potentials with a directional and scalable depth electrode array.

Journal of neural engineering·2023

Neural probe geometry significantly impacts tissue response. Thinner, wider probe edges reduce chronic inflammation and scarring, improving neural interface longevity.

Area of Science:

  • Neuroscience
  • Biomaterials Engineering
  • Tissue Engineering

Background:

  • Chronic inflammation and glial scarring around neural implants can degrade device performance and longevity.
  • Understanding the relationship between neural probe design and tissue response is crucial for developing effective neural interfaces.

Purpose of the Study:

  • To investigate how the size and shape of microscale neural probes influence the chronic reactive tissue response.
  • To compare tissue responses to different neural probe geometries, specifically focusing on shank vs. lateral platform designs.

Main Methods:

  • Microfabricated parylene-based neural probes with varying platform designs (solid and lattice) were implanted in rat cerebral cortex for 4 weeks.
  • Immunohistochemistry was used to assess neuronal density, non-neuronal density (NND), astrocyte and microglia reactivity, and extracellular matrix deposition (fibronectin, laminin).

Related Experiment Videos

  • Tissue responses were quantified in regions adjacent to the probe shank and the lateral platform edge.

    • Main Results:

    • Non-neuronal density (NND) significantly increased and neuronal density decreased near the probe interface.
    • The lateral edge of the probe platform exhibited a significantly reduced non-neuronal density (129% increase) compared to the shank (425% increase).
    • Neuronal density was higher, and microglia reactivity and protein deposition were lower at the lateral platform edge compared to the shank, irrespective of platform design.

    Conclusions:

    • Neural probe geometry, particularly the design of the lateral edges, is a critical factor in mitigating chronic tissue encapsulation.
    • Optimizing probe geometry can lead to improved biocompatibility and long-term stability of neural implants.
    • These findings provide valuable insights for the design of next-generation neural probes with reduced foreign body response.