Related Experiment Video

Updated: Jul 14, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Risk of target lesion revascularization after coronary stenting in patients with and without chronic kidney disease

David Charytan1, John P Forman, Donald E Cutlip

  • 1Department of Medicine, Brigham and Women's Hospital, Renal Division, Clinical Biometrics, 1 Brigham Circle, 3rd Floor, Boston, MA 02115, USA. dcharytan@partners.org

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|May 23, 2007
PubMed

Insights

Mild to moderate chronic kidney disease (CKD) did not increase the overall risk of target lesion revascularization after coronary stenting. However, long-term outcomes may be less favorable for patients with CKD, warranting further investigation.

Area of Science:

  • Cardiology
  • Nephrology
  • Interventional Cardiology

Background:

  • High restenosis rates are noted in advanced renal failure patients post-percutaneous coronary intervention (PCI) with stenting.
  • The impact of mild to moderate chronic kidney disease (CKD) on target lesion revascularization (TLR) after coronary stenting remains uncertain.

Purpose of the Study:

  • To investigate the association between mild to moderate CKD and short-term and long-term TLR risk following coronary stenting.
  • To compare the effectiveness of coronary stenting in patients with and without mild to moderate CKD.

Main Methods:

  • Analysis of 1228 patients from four randomized trials undergoing elective coronary angioplasty with stenting.
  • Prospective 5-year follow-up and Cox proportional hazards regression to assess TLR risk in patients with vs. without mild to moderate CKD.

Main Results:

  • No significant increase in overall TLR risk was observed for mild (HR 1.07) or moderate (HR 0.95) CKD.
  • A non-significant trend towards increased late TLR risk (HR 1.40) was noted in patients with mild to moderate CKD.
  • TLR was required in 16.7% of patients overall, with 4.8% occurring after the first year.

Conclusions:

  • Coronary stenting demonstrates similar short-term effectiveness in patients with mild to moderate CKD and those with normal renal function.
  • While late TLR is uncommon, long-term results of coronary stenting may be less favorable in patients with CKD.
  • Further research into long-term outcomes for CKD patients undergoing stenting is warranted.
Abstract

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...