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Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using
Yanjun Li1, M Hong Nguyen, Hartmut Derendorf
1Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.
Antimicrobial Agents and Chemotherapy
|May 23, 2007
Abstract:
We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.
