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Updated: Jul 14, 2026

Detection and Isolation of Campylobacter spp. from Raw Meat
Published on: February 23, 2024
Heterogeneity of a Campylobacter jejuni protein that is secreted through the flagellar filament
Frédéric Poly1, Cheryl Ewing, Scarlett Goon
1Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Abstract:
Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.
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